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It happened around 3 a.m. Saturday, April 4 in Mineola.
A Lexus sedan, being operated by a 27-year-old man, was traveling eastbound on Jericho Turnpike where it intersects with Willis Avenue when it was involved in a collision with a Chevrolet SUV operated by a 38-year-old man, Nassau County Police said.
The Chevrolet SUV then collided with a Jeep SUV operated by a 26-year-old woman, according to police.
The Lexus sedan proceeded to collide with a fence at 113 Jericho Turnpike and two businesses located at 99 Jericho Turnpike and 105 Jericho Turnpike.
The operator of the Lexus and a 28-year-old female passenger were transported to area hospitals with serious injuries.
Two additional parties involved were transported to area hospitals with minor injuries.
The investigation is ongoing.
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